Issue 12, 2021, Issue in Progress

A new pH/NIR responsive theranostic agent for magnetic resonance imaging guided synergistic therapy

Abstract

New nano-reagents with diagnostic imaging and therapeutic functions are very important for precision medicine against cancer. In this work, a new nanotheraontic agent for magnetic resonance imaging (MRI) guided combined photothermal therapy (PTT) and chemotherapy was constructed based on polydopamine (PDA) functionalized copper ferrite nanospheres (PDA@CFNs). The high relaxivity makes it possible for PDA@CFNs to become a promising MRI contrast agent, providing necessary and exhaustive information for tumor diagnosis. In addition, because both CFNs and PDA have strong near-infrared (NIR) absorption, PDA@CFNs exhibit excellent photothermal performance. Highly effective tumor ablation is achieved in a mouse model through PTT and pH/NIR triggered on-demand chemotherapy. These findings reveal that constructing smart pH/NIR responsive multifunctional theranostic agents is a feasible strategy for precision cancer therapy.

Graphical abstract: A new pH/NIR responsive theranostic agent for magnetic resonance imaging guided synergistic therapy

Supplementary files

Article information

Article type
Paper
Submitted
10 Nov 2020
Accepted
26 Jan 2021
First published
04 Feb 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 6472-6476

A new pH/NIR responsive theranostic agent for magnetic resonance imaging guided synergistic therapy

Y. Du, D. Wang, S. Wang, W. Li and J. Suo, RSC Adv., 2021, 11, 6472 DOI: 10.1039/D0RA09538A

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