Drug dual-release matrix proprieties and the correlations with nanostructure aggregation kinetics for siloxane-polyether/hydrogel nanocomposites

Abstract

The influence of hydrogels on the nanostructural formation of siloxane-polyether nanocomposites was examined. The nanostructure was studied with small-angle X-ray scattering (SAXS) to determine the siloxane nanostructure aggregation mechanisms. The interactions between matrix and drug were examined by infrared spectroscopy to verify the compatibility of the drug with the matrix. For in vitro release tests Piroxicam was used as a model molecule. The variation of the different types of hydrogels, bis-acrylamide (BIS), poly(acrylamide-co-acrylic acid) (PAM) and polyvinylpyrrolidone (PVP) can modify the drug release profiles. The release behaviour was determined to be composed of two concomitant release mechanisms. The first is in the early stages of drug release, governed by erosion, diffusion and swelling and the second, in advanced stages of release, typical of diffusion through pores. These dependencies were found to be correlated to the physical and chemical properties of the nanocomposites, including the interactions disturbing polycondensation formation. The release rate depends on intramolecular matrix–matrix and intermolecular drug–matrix interactions, as well as a crystalline state of the matrix.