An MeSeSO3Na reagent for oxidative aminoselenomethylation of maleimides

Abstract

Herein, we describe the design and synthesis of an MeSeSO₃Na reagent, which proved to be a versatile selenomethylation reagent for copper-catalyzed aminoselenomethylation of maleimides. This simple and efficient catalytic system is applicable for late-stage vinylselenomethylation of secondary amine-containing pharmaceuticals and two-fold aminoselenomethylation reactions. Most importantly, the current strategy provides a direct and convenient method for the incorporation of the SeCD₃ group.