A photoredox- or metal-catalyzed three-component cyanoalkylsulfonylation reaction of 1-(allyloxy)-2-(1-arylvinyl)benzenes, potassium metabisulfite, and cycloketone oxime esters: synthesis of cyanoalkylsulfonylated benzoxepines

Abstract

A visible light photocatalyzed or metal-catalyzed three-component cyanoalkylsulfonylation of 1-(allyloxy)-2-(1-arylvinyl)benzenes, potassium metabisulfite and cyclobutanone oxime esters is developed. This reaction provides a direct approach to diverse cyanoalkylsulfonylated benzoxepines in moderate to good yields. This transformation displays a wide substrate scope, wide functional group tolerance and the potential for product derivatization.

Graphical abstract: A photoredox- or metal-catalyzed three-component cyanoalkylsulfonylation reaction of 1-(allyloxy)-2-(1-arylvinyl)benzenes, potassium metabisulfite, and cycloketone oxime esters: synthesis of cyanoalkylsulfonylated benzoxepines

Supplementary files

Article information

Article type
Research Article
Submitted
09 Aug 2021
Accepted
02 Sep 2021
First published
03 Sep 2021

Org. Chem. Front., 2021, Advance Article

A photoredox- or metal-catalyzed three-component cyanoalkylsulfonylation reaction of 1-(allyloxy)-2-(1-arylvinyl)benzenes, potassium metabisulfite, and cycloketone oxime esters: synthesis of cyanoalkylsulfonylated benzoxepines

N. Zhou, S. Wu, K. Kuang, Z. Xia, Q. Xu and M. Zhang, Org. Chem. Front., 2021, Advance Article , DOI: 10.1039/D1QO01183A

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