Iron-catalyzed C–F bond silylation and borylation of fluoroarenes

Abstract

Iron-catalyzed functionalization of inert bonds has scarcely been documented. Herein, we report an iron-catalyzed method for the silylation and borylation of (hetero)aromatic fluorides. This protocol features a wide range of substrates, high efficiency, and good compatibility with functional groups. Moreover, it also enables late-stage silylation of some pharmaceuticals, thus providing an excellent route for obtaining valuable pharmaceutical intermediates.