The Mizoroki–Heck reaction initiated formal C(sp3)–H arylation of carbonyl compounds

Abstract

Herein, we present a Mizoroki–Heck reaction initiated formal C(sp³)–H arylation of α-methylcinnamaldehydes. The reaction proceeds smoothly under phosphane-free conditions, and provides a facile method to access important α-methylcinnamaldehyde derivatives with good functional groups tolerance and good stereoselectivity. The obtained product is further converted into a substituted allylic alcohol and diene easily.