Intramolecular difunctionalization of methylenecyclopropanes tethered with carboxylic acid by visible-light photoredox catalysis

Abstract

We have developed a visible-light photoredox catalyzed intramolecular difunctionalization of MCPs to access spiro[cyclopropane-1,2-indan]one from easily prepared methylenecyclopropanes tethered with carboxylic acid. The reaction can be performed under mild conditions, affording target products in excellent yields with a high atomic economy, and this cyclization reaction can be extended to gram scale synthesis. The products could be transformed to 1-indanone motifs existing in many natural products and bioactive compounds.