Organocatalytic stereoselective 1,6-addition of thiolacetic acids to alkynyl indole imine methides: access to axially chiral sulfur-containing tetrasubstituted allenes†
Pengfei
Li 
*b
and
Wenjun
Li
*a
*b
and
Wenjun
Li
*a
Abstract
A chiral phosphoric acid-catalyzed enantioselective 1,6-conjugate addition of thiolacetic acid to alkynyl indole imine methide in situ formed from α-(3-indolyl) propargylic alcohol has been established, which enables the formation of axially chiral sulfur-containing tetrasubstituted allenes in generally high efficiency with stereoselectivity.
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