Issue 9, 2021

Palladium-catalyzed carbonylative cyclization of 2-alkynylanilines and aryl iodides to access N-acyl indoles

Abstract

A palladium-catalyzed carbonylative synthesis of N-acyl indoles from 2-alkynylanilines and aryl iodides has been developed. Using benzene-1,3,5-triyl triformate (TFBen) as the CO source, the reaction produced a variety of N-acyl indoles in a facile manner with high yields.

Graphical abstract: Palladium-catalyzed carbonylative cyclization of 2-alkynylanilines and aryl iodides to access N-acyl indoles

Supplementary files

Article information

Article type
Research Article
Submitted
04 Feb 2021
Accepted
17 Feb 2021
First published
19 Feb 2021

Org. Chem. Front., 2021,8, 1926-1929

Palladium-catalyzed carbonylative cyclization of 2-alkynylanilines and aryl iodides to access N-acyl indoles

L. Yao, Y. Shang, J. Wang, A. Pan, J. Ying and X. Wu, Org. Chem. Front., 2021, 8, 1926 DOI: 10.1039/D1QO00205H

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