Issue 7, 2021
From the journal:

Organic Chemistry Frontiers

Catalytic synthesis of functionalized amidines via cobalt-carbene radical coupling with isocyanides and amines†

Zheng-Yang Gu, ORCID logo ‡ab   Hui Han,‡b   Zi-Yin Li,a   Shun-Jun Ji ORCID logo *c  and  Ji-Bao Xia ORCID logo *b  

* Corresponding authors

a College of Textiles and Clothing & Key Laboratory for Advanced Technology in Environmental Protection of Jiangsu Province, Yancheng Institute of Technology, Yancheng, China

b State Key Laboratory for Oxo Synthesis and Selective Oxidation, Center for Excellence in Molecular Synthesis, Suzhou Research Institute of LICP, Lanzhou Institute of Chemical Physics (LICP), University of Chinese Academy of Sciences, Chinese Academy of Sciences, Lanzhou 730000, China
E-mail: jibaoxia@licp.cas.cn

c College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, China
E-mail: shunjin@suda.edu.cn

Abstract

An atom- and step-economic multi-component cobalt-catalyzed synthesis of amidines has been reported by using amines, isocyanides, and diazo compounds as carbene sources. This protocol provides a synthetically simple, highly efficient strategy for the straightforward synthesis of functionalized amidines with a range of substrates.

Graphical abstract: Catalytic synthesis of functionalized amidines via cobalt-carbene radical coupling with isocyanides and amines

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Article information

DOI
https://doi.org/10.1039/D1QO00063B
Article type
Research Article
Submitted
15 Jan 2021
Accepted
04 Feb 2021
First published
05 Feb 2021

Org. Chem. Front., 2021,8, 1544-1550

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Catalytic synthesis of functionalized amidines via cobalt-carbene radical coupling with isocyanides and amines

Z. Gu, H. Han, Z. Li, S. Ji and J. Xia, Org. Chem. Front., 2021, 8, 1544 DOI: 10.1039/D1QO00063B

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