Designing lanthanide coordination nanoframeworks as X-ray responsive radiosensitizers for efficient cancer therapy

Hanjie Zhang; Kun Ye; Xiaoting Huang; Xia Lin; Li Ma; Tianfeng Chen

doi:10.1039/D1QI00442E

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Designing lanthanide coordination nanoframeworks as X-ray responsive radiosensitizers for efficient cancer therapy†

Hanjie Zhang,‡^a Kun Ye,‡^a Xiaoting Huang,‡^a Xia Lin,^a Li Ma*^a and Tianfeng Chen

*^a

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* Corresponding authors

^a Department of Chemistry and Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Jinan University, Guangzhou, 510632, China
E-mail: chem_mali@jnu.edu.cn, tchentf@jnu.edu.cn

Abstract

A series of three-dimensional Ln-based coordination frameworks were designed and synthesized. After nanolization, they show great potential as efficient and low toxic X-ray responsive radiosensitizers for the treatment of cervical cancer. The experimental data showed that these Ln-based nanoframeworks induced G0/G1 arrest mainly through the increase of the intracellular ROS level.

This article is part of the themed collection: 2021 Inorganic Chemistry Frontiers HOT articles

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Article information

DOI: https://doi.org/10.1039/D1QI00442E
Article type: Research Article
Submitted: 04 Apr 2021
Accepted: 10 May 2021
First published: 14 May 2021

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Inorg. Chem. Front., 2021,8, 3433-3439

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Designing lanthanide coordination nanoframeworks as X-ray responsive radiosensitizers for efficient cancer therapy

H. Zhang, K. Ye, X. Huang, X. Lin, L. Ma and T. Chen, Inorg. Chem. Front., 2021, 8, 3433 DOI: 10.1039/D1QI00442E

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Inorganic Chemistry Frontiers

Designing lanthanide coordination nanoframeworks as X-ray responsive radiosensitizers for efficient cancer therapy†

Abstract

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Designing lanthanide coordination nanoframeworks as X-ray responsive radiosensitizers for efficient cancer therapy

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