Issue 15, 2021

Synthetic approaches for copolymers containing nucleic acids and analogues: challenges and opportunities

Abstract

Deep integration of nucleic acids with other classes of materials has become the basis of many useful technologies. Among these biohybrids, nucleic acid-containing copolymers have seen rapid development in both chemistry and applications. This review focuses on the various synthetic approaches for accessing nucleic acid–polymer biohybrids spanning post-polymerization conjugation, nucleic acids in polymerization, solid-phase synthesis, and nucleoside/nucleobase-functionalized polymers. We highlight the challenges associated with working with nucleic acids with each approach and the ingenuity of the solutions, with the hope of lowering the entry barrier and inspiring further investigations in this exciting area.

Graphical abstract: Synthetic approaches for copolymers containing nucleic acids and analogues: challenges and opportunities

Article information

Article type
Review Article
Submitted
15 Dec 2020
Accepted
17 Mar 2021
First published
29 Mar 2021

Polym. Chem., 2021,12, 2193-2204

Synthetic approaches for copolymers containing nucleic acids and analogues: challenges and opportunities

H. Lu, J. Cai and K. Zhang, Polym. Chem., 2021, 12, 2193 DOI: 10.1039/D0PY01707H

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