Rhodium-catalyzed C–H activation/cyclization of aryl sulfoximines with iodonium ylides towards polycyclic 1,2-benzothiazines

Abstract

The synthesis of 1,2-benzothiazine derivatives through rhodium-catalyzed C–H activation/cyclization of S-aryl sulfoximines with iodonium ylides was developed for the first time. In this report, C–H and N–H bond functionalization was realized towards a series of tricyclic and tetracyclic sulfoximine derivatives with moderate to excellent yields under simple reaction conditions.