Nickel-catalyzed cross-electrophile coupling of aryl chlorides with allylic alcohols

Abstract

Nickel-catalyzed cross-electrophile coupling of aryl chlorides with allylic alcohols proceeds readily under mild conditions in the presence of zinc powder and MgCl₂ to produce allylarenes in 25–92% yields. The reaction shows high regioselectivity and E/Z-selectivity, giving linear allylation products with an E configurated double bond when 1- or 3-arylallyl alcohols were used as the substrates. Functional groups including F, CF₃, COOEt, NMe₂, OMe, SiMe₃, OH and vinyl groups as well as nitrogen-containing heterocycles were tolerated.