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Lewis acid mediated cyclization: synthesis of 2 spirocyclohexylindolines

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Abstract

Herein, we report the synthesis of 2-spirocyclohexylindolines based on a Lewis acid mediated cyclization. This diastereoselective procedure provides the target structures in a straightforward way via dual activation.

Graphical abstract: Lewis acid mediated cyclization: synthesis of 2 spirocyclohexylindolines

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Article information


Submitted
17 Feb 2021
Accepted
29 Mar 2021
First published
30 Mar 2021

Org. Biomol. Chem., 2021, Advance Article
Article type
Communication

Lewis acid mediated cyclization: synthesis of 2 spirocyclohexylindolines

X. Kong, Z. Xiong, X. Zhi, X. Meng, J. Zhao, W. Chen and H. Zhang, Org. Biomol. Chem., 2021, Advance Article , DOI: 10.1039/D1OB00293G

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