Issue 6, 2021
From the journal:

Organic & Biomolecular Chemistry

Palladium-catalyzed dearomative cyclocarbonylation of allyl alcohol for the synthesis of quinolizinones†

Pengcheng Xu,ab   Bo Qian, ORCID logo *a   Zaojuan Qi,a   Bao Gao,c   Bin Hu ORCID logo *a  and  Hanmin Huang ORCID logo *ac  

* Corresponding authors

a State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P. R. China
E-mail: boqian@licp.cas.cn, hcom@licp.cas.cn, hanmin@ustc.edu.cn

b University of Chinese Academy of Sciences, Beijing 100049, P. R. China

c Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis, University of Science and Technology of China, Chinese Academy of Sciences, Hefei 230026, P. R. China

Abstract

An approach for the synthesis of quinolizinone with potential bioactivity has been developed via palladium-catalytic dearomative cyclocarbonylation of allyl alcohol. Diverse quinolizinone compounds could be attained with good efficiencies. A feasible reaction pathway could be a successive procedure of allylation, dearomatization, CO insertion and the Heck reaction.

Graphical abstract: Palladium-catalyzed dearomative cyclocarbonylation of allyl alcohol for the synthesis of quinolizinones

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Article information

DOI
https://doi.org/10.1039/D0OB02529A
Article type
Communication
Submitted
18 Dec 2020
Accepted
10 Jan 2021
First published
11 Jan 2021

Org. Biomol. Chem., 2021,19, 1274-1277

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Palladium-catalyzed dearomative cyclocarbonylation of allyl alcohol for the synthesis of quinolizinones

P. Xu, B. Qian, Z. Qi, B. Gao, B. Hu and H. Huang, Org. Biomol. Chem., 2021, 19, 1274 DOI: 10.1039/D0OB02529A

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