Issue 2, 2021

Biocatalytic synthesis of non-vicinal aliphatic diols

Abstract

Biocatalysts are receiving increased attention in the field of selective oxyfunctionalization of C–H bonds, with cytochrome P450 monooxygenases (CYP450s), and the related peroxygenases, leading the field. Here we report on the substrate promiscuity of CYP505A30, previously characterized as a fatty acid hydroxylase. In addition to its regioselective oxyfunctionalization of saturated fatty acids (ω-1 – ω-3 hydroxylation), primary fatty alcohols are also accepted with similar regioselectivities. Moreover, alkanes such as n-octane and n-decane are also readily accepted, allowing for the production of non-vicinal diols through sequential oxygenation.

Graphical abstract: Biocatalytic synthesis of non-vicinal aliphatic diols

Supplementary files

Article information

Article type
Paper
Submitted
13 Oct 2020
Accepted
03 Dec 2020
First published
08 Dec 2020

Org. Biomol. Chem., 2021,19, 439-445

Biocatalytic synthesis of non-vicinal aliphatic diols

A. C. Ebrecht, J. C. Aschenbrenner, M. S. Smit and D. J. Opperman, Org. Biomol. Chem., 2021, 19, 439 DOI: 10.1039/D0OB02086A

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