Ti2N MXene-based Nanosystem with Ultrahigh Drug Loading for Dual-strategy Synergistic Oncotherapy

Abstract

The exploration of MXenes, especially nitride MXenes, in the field of theranostic nanomedicine is still in its infancy. Here, towards synergistic chemo-photothermal oncotherapy, we demonstrate the first kind of 2D titanium nitride (Ti2N) MXene-based nanosystem (Ti2N@oSi) for dual-strategy synergistic oncotherapy. The unique structure of Ti2N nanosheets endows the drug carriers with an ultrahigh loading capacity of 796.3 % and an excellent NIR photothermal conversion efficiency of 41.6 % for chemo-photothermal therapy. After being coated with a biodegradable organosilica shell, the Ti2N@oSi nanocarriers show excellent characteristics of tumor targeting, pH/glutathione/photothermal-responsive drug release and dual drug combination chemotherapy. Both in-vitro and in-vivo therapeutic evaluations demonstrate the pronounced tumor growth inhibition effect and superior biocompatibility of Ti2N@oSi nanocarriers. The excellent drug loading ability, photothermal conversion ability and surface modifiability of Ti2N open up new opportunities for tumor microenvironment-targeted synergistic oncotherapy. This work is supposed to broaden the application of MXenes in nanomedicine and particularly, provide the first sight to the biomedical application of nitride MXenes.

Supplementary files

Article information

Article type
Paper
Submitted
21 Jun 2021
Accepted
08 Oct 2021
First published
13 Oct 2021

Nanoscale, 2021, Accepted Manuscript

Ti2N MXene-based Nanosystem with Ultrahigh Drug Loading for Dual-strategy Synergistic Oncotherapy

L. Li, Y. Lu, Z. Qian, Z. Yang, S. Zong, Z. Wang and Y. Cui, Nanoscale, 2021, Accepted Manuscript , DOI: 10.1039/D1NR04008A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements