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Biomimetic camouflage delivery strategies for cancer therapy

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Abstract

Cancer remains a significant challenge despite the progress in developing different therapeutic approaches. Nanomedicine has been explored as a promising novel cancer therapy. Recently, biomimetic camouflage strategies have been investigated to change the bio-fate of therapeutics and target cancer cells while reducing the unwanted exposure on normal tissues. Endogenous components (e.g., proteins, polysaccharides, and cell membranes) have been used to develop anticancer drug delivery systems. These biomimetic systems can overcome biological barriers and enhance tumor cell–specific uptake. The tumor-targeting mechanisms include ligand–receptor interactions and stimuli-responsive (e.g., pH-sensitive and light-sensitive) delivery. Drug delivery carriers composed of endogenous components represent a promising approach for improving cancer treatment efficacy. In this paper, different biomimetic drug delivery strategies for cancer treatment are reviewed with a focus on the discussion of their advantages and potential applications.

Graphical abstract: Biomimetic camouflage delivery strategies for cancer therapy

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Article information


Submitted
19 Feb 2021
Accepted
06 Apr 2021
First published
04 May 2021

Nanoscale, 2021, Advance Article
Article type
Review Article

Biomimetic camouflage delivery strategies for cancer therapy

A. M. Asrorov, Z. Gu, F. Li, L. Liu and Y. Huang, Nanoscale, 2021, Advance Article , DOI: 10.1039/D1NR01127H

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