Issue 6, 2021

Laser nanobubbles induce immunogenic cell death in breast cancer

Abstract

Recent advances in immunotherapy have highlighted a need for therapeutics that initiate immunogenic cell death in tumors to stimulate the body's immune response to cancer. This study examines whether laser-generated bubbles surrounding nanoparticles (“nanobubbles”) induce an immunogenic response for cancer treatment. A single nanosecond laser pulse at 1064 nm generates micron-sized bubbles surrounding gold nanorods in the cytoplasm of breast cancer cells. Cell death occurred in cells treated with nanorods and irradiated, but not in cells with irradiation treatment alone. Cells treated with nanorods and irradiation had increased damage-associated molecular patterns (DAMPs), including increased expression of chaperone proteins human high mobility group box 1 (HMGB1), adenosine triphosphate (ATP), and heat shock protein 70 (HSP70). This enhanced expression of DAMPs led to the activation of dendritic cells. Overall, this treatment approach is a rapid and highly specific method to eradicate tumor cells with simultaneous immunogenic cell death signaling, showing potential as a combination strategy for immunotherapy.

Graphical abstract: Laser nanobubbles induce immunogenic cell death in breast cancer

Supplementary files

Article information

Article type
Paper
Submitted
14 Sep 2020
Accepted
27 Jan 2021
First published
27 Jan 2021

Nanoscale, 2021,13, 3644-3653

Laser nanobubbles induce immunogenic cell death in breast cancer

H. T. M. Nguyen, N. Katta, J. A. Widman, E. Takematsu, X. Feng, S. A. Torres-Hurtado, T. Betancourt, A. B. Baker, L. J. Suggs, T. E. Milner and J. W. Tunnell, Nanoscale, 2021, 13, 3644 DOI: 10.1039/D0NR06587K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements