Issue 1, 2022

Anti-mycobacterial natural products and mechanisms of action

Abstract

Covering: up to June, 2020

Tuberculosis (TB) continues to be a major disease with high mortality and morbidity globally. Drug resistance and long duration of treatment make antituberculosis drug discovery more challenging. In this review, we summarize recent advances on anti-TB natural products (NPs) and their potential molecular targets in cell wall synthesis, protein production, energy generation, nucleic acid synthesis and other emerging areas. We highlight compounds with activity against drug-resistant TB, and reveal several novel targets including Mtb biotin synthase, ATP synthase, 1,4-dihydroxy-2-naphthoate prenyltransferase and biofilms. These anti-TB NPs and their targets could facilitate target-based screening and accelerate TB drug discovery.

Graphical abstract: Anti-mycobacterial natural products and mechanisms of action

Supplementary files

Article information

Article type
Review Article
Submitted
21 Feb 2021
First published
06 Jul 2021

Nat. Prod. Rep., 2022,39, 77-89

Anti-mycobacterial natural products and mechanisms of action

J. Han, X. Liu, L. Zhang, R. J. Quinn and Y. Feng, Nat. Prod. Rep., 2022, 39, 77 DOI: 10.1039/D1NP00011J

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