A peptide-functionalised dendronised polymer for selective transfection in human liver cancer cells

Abstract

Achieving high transfection efficiencies and tumour cell specificity are key milestones in the development of non-viral gene delivery agents. Here, we demonstrate the effectiveness of a dendronised polymer system functionalised with a targeting peptide to achieve highly selective transient transfection of liver cancer cells over normal non-transformed hepatocytes. The highly specific delivery agent has potential applications in gene therapy and may be worthy of further investigation for the treatment of liver cancer.