Issue 8, 2021
From the journal:

New Journal of Chemistry

NBS-assisted palladium-catalyzed bromination/cross-coupling reaction of 2-alkynyl arylazides with KSCN: an efficient method to synthesize 3-thiocyanindoles†

Guiwen Hu,a   Ping Li,a   Zhiqiang Zhou,a   Fan Yang,a   Shijie Xu,a   Hui Fan,a   Xuechun Zhaoa  and  Xiaoxiang Zhang ORCID logo *a  

* Corresponding authors

a Co-Innovation Center for Efficient Processing and Utilization of Forest Products, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China
E-mail: zhangxiaoxiang@njfu.edu.cn

Abstract

A novel and efficient method for the synthesis of 3-thiocyanindoles from 2-alkynyl arylazides with KSCN is described. NBS (N-bromosuccinimide) plays an important role in this cascade bromination/cross-coupling reaction. This reaction provides the 3-thiocyanindole products in good to excellent yields under mild reaction conditions.

Graphical abstract: NBS-assisted palladium-catalyzed bromination/cross-coupling reaction of 2-alkynyl arylazides with KSCN: an efficient method to synthesize 3-thiocyanindoles

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Article information

DOI
https://doi.org/10.1039/D0NJ05894G
Article type
Paper
Submitted
03 Dec 2020
Accepted
20 Jan 2021
First published
21 Jan 2021

New J. Chem., 2021,45, 3828-3832

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NBS-assisted palladium-catalyzed bromination/cross-coupling reaction of 2-alkynyl arylazides with KSCN: an efficient method to synthesize 3-thiocyanindoles

G. Hu, P. Li, Z. Zhou, F. Yang, S. Xu, H. Fan, X. Zhao and X. Zhang, New J. Chem., 2021, 45, 3828 DOI: 10.1039/D0NJ05894G

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