Issue 15, 2021

Chromene–triazole-pyrimidine based chemosensor therapeutics for the in vivo and in vitro detection of Fe3+ ions

Abstract

The development of a series of chromene–pyrimidine triad molecules for the selective detection of Fe3+ is described. The new chemosensors were synthesized through the sequential use of multicomponent reactions (MCRs) and click chemistry marking its ease and cost effectiveness. The sensor molecules showed turn-off fluorescence towards Fe3+ with an extremely low limit of detection (LOI) and a strong affinity to cancer causing CDK2 proteins with binding energy closer to −9.8 kcal mol−1 as indicated by the molecular docking studies. The free hydrophilic handles present on the sensors are advantageous for binding with cellular Fe3+ demonstrating the potential of these molecules as therapeutics for iron overloading diseases. The therapeutic potential is further illustrated via cytotoxicity studies against the human cervical cancer cell line HeLa, which showed a very low IC50 value of 15 μg mL−1.

Graphical abstract: Chromene–triazole-pyrimidine based chemosensor therapeutics for the in vivo and in vitro detection of Fe3+ ions

Supplementary files

Article information

Article type
Paper
Submitted
24 Nov 2020
Accepted
13 Mar 2021
First published
15 Mar 2021

New J. Chem., 2021,45, 6760-6767

Chromene–triazole-pyrimidine based chemosensor therapeutics for the in vivo and in vitro detection of Fe3+ ions

A. Shamsiya and D. Bahulayan, New J. Chem., 2021, 45, 6760 DOI: 10.1039/D0NJ05697A

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