Issue 2, 2021

Stable π-radical nanoparticles as versatile photosensitizers for effective hypoxia-overcoming photodynamic therapy

Abstract

We report the first demonstration using a stable π-radical as a versatile photosensitizer for hypoxia-overcoming photodynamic therapy. After self-assembling the radical molecules into radical nanoparticles (NPs), the NPs show good water dispersibility, good biocompatibility, broad near-infrared (NIR) absorption and emission at ∼800 nm. Significantly, the radical NPs remain stable in various biological mediums, after 100 days exposure to the ambient environment, and even after long-term laser irradiation, which is superior to many reported radical-based materials. More importantly, upon 635 nm laser irradiation, sufficient superoxide radical (O2˙) generation and in vitro cytotoxicity were observed addressing the most important hurdle for successful PDT in the oxygen-deficient tumor microenvironment. In addition, the radical NPs are also demonstrated to have effective in vivo PDT efficacy, and excellent biosafety.

Graphical abstract: Stable π-radical nanoparticles as versatile photosensitizers for effective hypoxia-overcoming photodynamic therapy

Supplementary files

Article information

Article type
Communication
Submitted
14 Aug 2020
Accepted
05 Nov 2020
First published
05 Nov 2020

Mater. Horiz., 2021,8, 571-576

Stable π-radical nanoparticles as versatile photosensitizers for effective hypoxia-overcoming photodynamic therapy

X. Cui, G. Lu, S. Dong, S. Li, Y. Xiao, J. Zhang, Y. Liu, X. Meng, F. Li and C. Lee, Mater. Horiz., 2021, 8, 571 DOI: 10.1039/D0MH01312A

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