Issue 10, 2021
From the journal:

RSC Medicinal Chemistry

Virtual screening and in vitro validation identifies the first reported inhibitors of Salmonella enterica HPPK†

Ronel Müller,a   Tiaan M. Gerwel,b   Magambo Phillip Kimuda, ORCID logo c   Özlem Tastan Bishop,c   Clinton G. L. Veale ORCID logo *a  and  Heinrich C. Hoppe ORCID logo *d  

* Corresponding authors

a School of Chemistry and Physics, Pietermaritzburg Campus, University of KwaZulu-Natal, Private Bag X01, Scottsville, South Africa
E-mail: VealeC@ukzn.ac.za

b Faculty of Pharmacy, Rhodes University, Makhanda, South Africa

c Research Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Makhanda, South Africa

d Department of Biochemistry and Microbiology, Rhodes University, Makhanda, South Africa
E-mail: H.Hoppe@ru.ac.za

Abstract

HPPK, which directly precedes DHPS in the folate biosynthetic pathway, is a promising but chronically under-exploited anti-microbial target. Here we report the identification of new S. enterica HPPK inhibitors, offering potential for new resistance circumventing S. enterica therapies as well as avenues for diversifying the current HPPK inhibitor space.

Graphical abstract: Virtual screening and in vitro validation identifies the first reported inhibitors of Salmonella enterica HPPK

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Article information

DOI
https://doi.org/10.1039/D1MD00237F
Article type
Research Article
Submitted
14 Jul 2021
Accepted
23 Aug 2021
First published
23 Aug 2021

RSC Med. Chem., 2021,12, 1750-1756

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Virtual screening and in vitro validation identifies the first reported inhibitors of Salmonella enterica HPPK

R. Müller, T. M. Gerwel, M. P. Kimuda, Ö. T. Bishop, C. G. L. Veale and H. C. Hoppe, RSC Med. Chem., 2021, 12, 1750 DOI: 10.1039/D1MD00237F

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