Issue 7, 2021

Recent advances in urea- and thiourea-containing compounds: focus on innovative approaches in medicinal chemistry and organic synthesis

Abstract

Urea and thiourea represent privileged structures in medicinal chemistry. Indeed, these moieties constitute a common framework of a variety of drugs and bioactive compounds endowed with a broad range of therapeutic and pharmacological properties. Herein, we provide an overview of the state-of-the-art of urea and thiourea-containing pharmaceuticals. We also review the diverse approaches pursued for (thio)urea bioisosteric replacements in medicinal chemistry applications. Finally, representative examples of recent advances in the synthesis of urea- and thiourea-based compounds by enabling chemical tools are discussed.

Graphical abstract: Recent advances in urea- and thiourea-containing compounds: focus on innovative approaches in medicinal chemistry and organic synthesis

Article information

Article type
Review Article
Submitted
22 Feb 2021
Accepted
23 Apr 2021
First published
13 May 2021

RSC Med. Chem., 2021,12, 1046-1064

Recent advances in urea- and thiourea-containing compounds: focus on innovative approaches in medicinal chemistry and organic synthesis

R. Ronchetti, G. Moroni, A. Carotti, A. Gioiello and E. Camaioni, RSC Med. Chem., 2021, 12, 1046 DOI: 10.1039/D1MD00058F

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