Issue 19, 2021

The detection of Al3+ and Cu2+ ions using isonicotinohydrazide-based chemosensors and their application to live-cell imaging

Abstract

A new Schiff base receptor (3) was synthesized by an equimolar reaction between isonicotinic hydrazide and 2,4-dihydroxybenzaldehyde in ethanol. Receptor 3 demonstrated excellent selectivity and sensitivity towards Cu2+ ions and Al3+ ions by UV-vis absorption spectroscopy and fluorescence spectroscopy, respectively. Receptor 3 showed a detectable color change from colorless to yellow with a red-shift (Δλ ≈ 70 nm) in the absorption spectra in the presence of Cu2+. In the emission study of 3, Al3+ showed significant fluorescent enhancement (λem = 473 nm) over a wide range of tested metal ions. The quantum yield of receptor 3 (Φ = 0.0021) increases ∼230 folds in the presence of Al3+ ions to form receptor 3·Al3+ complex (Φ = 0.484). Receptor 3 showed high selectivity for Al3+ with a Ka of 4.8 × 104 M−1 and LOD of 3.0 nM. In comparison, Ka for Cu2+ was 1.3 × 104 M−1 and LOD of 1.9 μM. Receptor 3 is an excellent chemosensor for detecting Al3+ ions as indicated by its nanomolar range LOD. The quick response, easy-synthesis, and high sensitivity make receptor 3 an ideal sensor for detecting Al3+ ions in a semi-aqueous medium and living cells.

Graphical abstract: The detection of Al3+ and Cu2+ ions using isonicotinohydrazide-based chemosensors and their application to live-cell imaging

Associated articles

Supplementary files

Article information

Article type
Paper
Submitted
29 Jun 2021
Accepted
15 Aug 2021
First published
17 Aug 2021
This article is Open Access
Creative Commons BY-NC license

Mater. Adv., 2021,2, 6306-6314

The detection of Al3+ and Cu2+ ions using isonicotinohydrazide-based chemosensors and their application to live-cell imaging

I. Song, P. Torawane, J. Lee, S. D. Warkad, A. Borase, S. K. Sahoo, S. B. Nimse and A. Kuwar, Mater. Adv., 2021, 2, 6306 DOI: 10.1039/D1MA00564B

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