Continuous-flow electro-oxidative coupling of sulfides with activated methylene compounds leading to sulfur ylides

Abstract

An unprecedentedly straightforward electro-oxidative coupling of sulfides with activated methylene compounds to synthesize sulfur ylides has been developed. Good to excellent yields can be obtained under catalyst- and oxidant-free conditions at room temperature. Owing to the use of continuous-flow electrochemical setups, this green, mild and practical electrosynthesis features high efficiency and excellent functional group tolerance and is easy to scale up.