Issue 24, 2021

Evaluation and development of a novel pre-treatment method for mulberry leaves to enhance their bioactivity via enzymatic degradation of GAL-DNJ to DNJ

Abstract

Mulberry leaves are rich in 1-deoxynojirimycin (DNJ) and 2-O-α-D-galactopyranosyl-deoxynojirimycin (GAL-DNJ). Compared to DNJ, the bioactive potency of GAL-DNJ is low. We proposed that the conversion of GAL-DNJ into DNJ may improve its bioavailability. We evaluated this hypothesis and constructed a novel enzymatic-based method to induce the hydrolysis of GAL-DNJ to DNJ in order to improve the therapeutic potency of mulberry leaves.

Graphical abstract: Evaluation and development of a novel pre-treatment method for mulberry leaves to enhance their bioactivity via enzymatic degradation of GAL-DNJ to DNJ

Supplementary files

Article information

Article type
Communication
Submitted
17 Jul 2021
Accepted
16 Oct 2021
First published
10 Nov 2021

Food Funct., 2021,12, 12250-12255

Evaluation and development of a novel pre-treatment method for mulberry leaves to enhance their bioactivity via enzymatic degradation of GAL-DNJ to DNJ

S. Takasu, I. S. Parida, Y. Kojima, T. Kimura and K. Nakagawa, Food Funct., 2021, 12, 12250 DOI: 10.1039/D1FO02307A

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