Issue 18, 2021

Zinc delivery system constructed from food-borne nanoparticles derived from Undaria pinnatifida

Abstract

Food-borne nanoparticles from Undaria pinnatifida (UPFNs) were prepared and successfully applied as nanocarriers for microelement zinc delivery. UPFNs were spherical nanoparticles with average sizes of about 4.07 ± 1.09 nm, which chelated with zinc ions through amino nitrogen and carboxyl oxygen atoms as characterized by X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, and 1H nuclear magnetic resonance spectroscopy. Thermodynamic analysis revealed that the overall chelation process between UPFNs and zinc ions was a spontaneous enthalpy-driven endothermic reaction. Compared to zinc sulfate, UPFN–Zn2+ showed higher solubility both in phytic acid solution and the process of gastrointestinal digestion. Meanwhile, no obvious cytotoxicity was found in UPFNs and UPFN–Zn2+. Specifically, UPFN–Zn2+ could successfully rescue cell viability, DNA replication activity and restore cell proliferation ability in zinc-deficient cells induced by a specific zinc chelator TPEN. Overall, UPFNs might serve as efficient, stable, and safe nanocarriers for zinc delivery.

Graphical abstract: Zinc delivery system constructed from food-borne nanoparticles derived from Undaria pinnatifida

Supplementary files

Article information

Article type
Paper
Submitted
12 Jun 2021
Accepted
07 Jul 2021
First published
07 Jul 2021

Food Funct., 2021,12, 8626-8634

Zinc delivery system constructed from food-borne nanoparticles derived from Undaria pinnatifida

F. Qiao, X. Yu, S. Tie, Y. Chen, S. Hou and M. Tan, Food Funct., 2021, 12, 8626 DOI: 10.1039/D1FO01852C

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