Issue 31, 2021

Development of a multi-target anticancer Sn(ii) pyridine-2-carboxaldehyde thiosemicarbazone complex

Abstract

In this study, we proposed to design effective multi-target anticancer agents based on the chelation of nontoxic metals with ligands that possess anticancer activity. In total, five Sn(II) pyridine-2-carboxaldehyde thiosemicarbazone complexes are synthesized and their activities are tested. Among these complexes, C5 is found to show the highest cytotoxicity on investigating their structure-activity relationships. In addition, C5 not only exhibits an effective inhibitory effect against tumor growth in vivo, but also suppresses angiogenesis and restricts the metastasis of cancer cells in vitro. Multiple mechanisms underlie the antitumor effect of C5, and they include acting against DNA, inducing apoptosis, and inhibiting the activities of anti-apoptotic Bcl-xL protein, metalloproteinase MMP2 and topoisomerase II.

Graphical abstract: Development of a multi-target anticancer Sn(ii) pyridine-2-carboxaldehyde thiosemicarbazone complex

Supplementary files

Article information

Article type
Paper
Submitted
17 Apr 2021
Accepted
04 Jul 2021
First published
08 Jul 2021

Dalton Trans., 2021,50, 10909-10921

Development of a multi-target anticancer Sn(II) pyridine-2-carboxaldehyde thiosemicarbazone complex

J. Wu, T. Yang, X. Wang, W. Li, M. Pang, H. Sun, H. Liang and F. Yang, Dalton Trans., 2021, 50, 10909 DOI: 10.1039/D1DT01272J

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