A cancer stem cell (CSC) active, solution stable, silver(I) polymeric complex bearing a dithiacyclam ligand is reported. The complex displays similar potency towards CSCs to salinomycin in monolayer and three-dimensional cultures. Mechanistic studies suggest CSC death results from cytosol entry, an increase in intracellular reactive oxygen species, and caspase-dependent apoptosis.
A. Johnson, L. Iffland, K. Singh, U. Apfel and K. Suntharalingam, Dalton Trans., 2021, 50, 5779 DOI: 10.1039/D1DT01155C
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