Issue 18, 2021
From the journal:

Dalton Transactions

An unexpected in-solution instability of diiodido analogue of picoplatin complicates its biological characterization†

Pavel Štarha, ORCID logo *a   Bohuslav Drahoš ORCID logo a  and  Radovan Herchel ORCID logo a  

* Corresponding authors

a Department of Inorganic Chemistry, Faculty of Science, Palacký University in Olomouc, 17. listopadu 1192/12, 771 46 Olomouc, Czech Republic
E-mail: pavel.starha@upol.cz

Abstract

Complex cis-[PtI2(NH3)(pic)] (1; pic = 2-methylpyridine), a diiodido analogue of clinically studied picoplatin (2), is unstable in solution, which is intriguingly connected with the release of its pic ligand. This observation complicates the biological testing of e.g. cytotoxicity in human cancer cells for 1.

Graphical abstract: An unexpected in-solution instability of diiodido analogue of picoplatin complicates its biological characterization

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Article information

DOI
https://doi.org/10.1039/D1DT00740H
Article type
Communication
Submitted
04 Mar 2021
Accepted
06 Apr 2021
First published
06 Apr 2021

Dalton Trans., 2021,50, 6071-6075

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An unexpected in-solution instability of diiodido analogue of picoplatin complicates its biological characterization

P. Štarha, B. Drahoš and R. Herchel, Dalton Trans., 2021, 50, 6071 DOI: 10.1039/D1DT00740H

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