Issue 8, 2021

Lowest aqueous picomolar fluoride ions and in vivo aluminum toxicity detection by an aluminum(iii) binding chemosensor

Abstract

Aluminum toxicity in biological systems is a well-known issue yet remains as a prevalent and unsolvable problem due to the lack of proper molecular tools that can detect free aluminum(III) or Al(III) ions in vivo. Herein, we report a water-soluble photo-induced electron transfer (PET)-based turn-ON/OFF fluorometric chemosensor for the dual detection of Al(III) and fluoride ions in aqueous media with a nanomolar (∼1.7 × 10−9 M) and picomolar (∼2 × 10−12 M, lowest ever detection so far) detection limit, respectively. Fluoride ions in sea water could be detected as well as the recognition of non-contamination in drinking water. In addition, using live-cell microscopy, Al(III) ions were detected in live biological samples in vivo to aid establishing the aluminum-toxicity effect.

Graphical abstract: Lowest aqueous picomolar fluoride ions and in vivo aluminum toxicity detection by an aluminum(iii) binding chemosensor

Supplementary files

Article information

Article type
Paper
Submitted
13 Nov 2020
Accepted
28 Jan 2021
First published
29 Jan 2021

Dalton Trans., 2021,50, 3027-3036

Lowest aqueous picomolar fluoride ions and in vivo aluminum toxicity detection by an aluminum(III) binding chemosensor

M. Das, D. Maity, T. K. Acharya, S. Sau, C. Giri, C. Goswami and P. Mal, Dalton Trans., 2021, 50, 3027 DOI: 10.1039/D0DT03901B

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