Issue 1, 2021

Chromium-catalysed efficient N-formylation of amines with a recyclable polyoxometalate-supported green catalyst

Abstract

A simple and efficient protocol for the formylation of amines with formic acid, catalyzed by a polyoxometalate-based chromium catalyst, is described. Notably, this method shows excellent activity and chemoselectivity for the formylation of primary amines; diamines have also been successfully employed. Importantly, the chromium catalyst is potentially non-toxic, environmentally benign and safer than the widely used high valence chromium catalysts such as CrO3 and K2Cr2O7. The catalyst can be recycled several times with a negligible impact on activity. Finally, a plausible mechanism is provided based on the observation of intermediate and control experiments.

Graphical abstract: Chromium-catalysed efficient N-formylation of amines with a recyclable polyoxometalate-supported green catalyst

Supplementary files

Article information

Article type
Paper
Submitted
22 Sep 2020
Accepted
26 Oct 2020
First published
27 Oct 2020

Dalton Trans., 2021,50, 90-94

Chromium-catalysed efficient N-formylation of amines with a recyclable polyoxometalate-supported green catalyst

D. Dan, F. Chen, W. Zhao, H. Yu, S. Han and Y. Wei, Dalton Trans., 2021, 50, 90 DOI: 10.1039/D0DT03300F

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