Recent developments in asymmetric hydroformylation

Abstract

The recent literature on asymmetric hydroformylation is reviewed from the perspective of the ligand development. Much progress was made in the area of hybrid bidentate ligands containing one P-chiral phosphine and bidentate P-chiral phosphine ligands. A number of other hybrid bidentate ligands were developed and led to very good results. Chiral bisphosphine ligands have also been highly successful. Use of BINOL-based monodentate phosphites and phosphoramidites generally led to lower enantioselectivities. The substrate scope was tremendously expanded and now also includes 1,1-disubsituted alkenes.