Jump to main content
Jump to site search
SCHEDULED MAINTENANCE Close the message box

Maintenance work is planned for Monday 16 August 2021 from 07:00 to 23:59 (BST).

Website performance may be temporarily affected and you may not be able to access some PDFs or images. If this does happen, refreshing your web browser should resolve the issue. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 9, 2021

Homochiral metal–organic frameworks for enantioseparation

Author affiliations

Abstract

Obtaining homochiral compounds is of high importance to human health and environmental sustainability. Currently, enantioseparation is one of the most effective approaches to obtain homochiral compounds. Thanks to their controlled synthesis and high efficiency, homochiral metal–organic frameworks (HMOFs) are one of the most widely studied porous materials to enable enantioseparation. In this review, we discuss the chiral pocket model in depth as the key to unlock enantioselective separation mechanisms in HMOFs. In particular, we classify our discussion of these chiral pockets (also regarded as “molecular traps”) into: (a) achiral/chiral linker based helical channels as a result of packing modality; and (b) chiral pores inherited from chiral ligands. Driven by a number of mechanisms of enantioseparation, conceptual advances have been recently made in the design of HMOFs for achieving high enantioseparation performances. Herein, these are systematically categorised and discussed. Further we elucidate various applications of HMOFs as regards enantioseparation, systematically classifying them into their use for purification and related analytical utility according to the reported examples. Last but not the least, we discuss the challenges and perspectives concerning the rational design of HMOFs and their corresponding enantioseparations.

Graphical abstract: Homochiral metal–organic frameworks for enantioseparation

Article information


Submitted
31 Dec 2020
First published
22 Mar 2021

Chem. Soc. Rev., 2021,50, 5706-5745
Article type
Review Article

Homochiral metal–organic frameworks for enantioseparation

J. Liu, S. Mukherjee, F. Wang, R. A. Fischer and J. Zhang, Chem. Soc. Rev., 2021, 50, 5706 DOI: 10.1039/D0CS01236J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements