Variable Stoichiometry Cocrystals: Occurrence and Significance.
The occurrence of variable stoichiometry cocrystals offers the prospect to acquire more solid forms of the same system. The control of stoichiometry is extremely important concerning the purity and intellectual property (IP) protection. We have analysed structures, synthetic methodologies and properties of the reported variable stoichiometry organic cocrystals reported in last decade, with an expression on their control production for drug formulation plans. This review further fetches an understanding of the accountable reasons for the existence of stoichiometry variation in cocrystals that essentially result from the disparity in properties with IP coverage.