Cyclic chain displacement amplification-based dual-miRNA detection: a triple-line lateral flow strip for the diagnosis of lung cancer

Abstract

Herein, we developed a triple-line lateral flow strip-based platform combined with an miRNA-initiated cyclic chain displacement reaction for the rapid and simultaneous dual-miRNA detection of lung cancer in a single strip test. The simultaneous dual-miRNA detection platform was used for the analysis of clinical serum samples, and distinguished non-small cell lung cancer patients from heathy individuals.