Fenton-like reaction of the iron(ii)–histidine complex generates hydroxyl radicals: implications for oxidative stress and Alzheimer's disease

Abstract

The hydroxyl radical (˙OH), generated from Fenton/Fenton-like reactions of iron(II) species in biology, can oxidatively damage biomolecules, inducing oxidative stress and diseases. However, this common understanding has been questioned recently after a carbonate radical was observed from the Fenton-like reaction of the iron(II)–carbonate complex. Herein, we report that the Fenton-like reaction of the iron(II)–histidine complex, one major iron(II) species in blood plasma, can occur at neutral pH to generate ˙OH, not iron(IV). Our findings and critical analyses on relevant studies clarify the above doubt, reveal a new pathway of causing oxidative stress by the iron(II) species, and have implications for Alzheimer's disease.