Issue 81, 2021

Ruthenium(ii)-catalyzed C–H activation and (4+2) annulation of aromatic hydroxamic acid esters with allylic amides

Abstract

A (4+2) annulation under Ru(II)-catalysis is reported using aromatic hydroxamic acid esters as the oxidizing directing group and allylic amides as unactivated olefin coupling partners, delivering a wide variety of aminomethyl isoquinolinones in good to excellent yields. This annulation is distinctive as allylic congeners typically result in allylation and not the annulation. Late-stage derivatization of a bioactive synthetic bile acid has been showcased.

Graphical abstract: Ruthenium(ii)-catalyzed C–H activation and (4+2) annulation of aromatic hydroxamic acid esters with allylic amides

Supplementary files

Article information

Article type
Communication
Submitted
11 Aug 2021
Accepted
14 Sep 2021
First published
14 Sep 2021

Chem. Commun., 2021,57, 10536-10539

Ruthenium(II)-catalyzed C–H activation and (4+2) annulation of aromatic hydroxamic acid esters with allylic amides

C. K. Giri, S. Dana and M. Baidya, Chem. Commun., 2021, 57, 10536 DOI: 10.1039/D1CC04422B

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