Issue 91, 2021
From the journal:

Chemical Communications

Bidirectional modulation of microRNA with a clamp-like triplex switch for enhanced and programmed gene therapy†

Lihua Zhang,ab   Zhen Zou, ORCID logo c   Yanli Lei, ORCID logo *c   Zhihe Qing, ORCID logo c   Yu Zeng,c   Haiyan Sun,c   Feng Feng ORCID logo *ab  and  Ronghua Yang ORCID logo *cd  

* Corresponding authors

a School of Chemistry and Material Science, Shanxi Normal University, Linfen, China
E-mail: feng-feng64@263.net

b College of Chemistry and Chemical Engineering, Shanxi Datong University, Datong, China

c School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha, China
E-mail: leiyanli222@126.com, yangrh@pku.edu.cn

d College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, China

Abstract

A clamp-like triplex switch (CTS) able to simultaneously downregulate an overexpressed onco-miRNA and replenish the lost tumor-suppressive miRNA in a controllable manner was developed for enhanced gene therapy. Compared to the “unidirectional” regulation approach, the CTS displayed improved anti-tumor efficacy in vitro and was harmless to healthy cells.

Graphical abstract: Bidirectional modulation of microRNA with a clamp-like triplex switch for enhanced and programmed gene therapy

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Article information

DOI
https://doi.org/10.1039/D1CC04325K
Article type
Communication
Submitted
07 Aug 2021
Accepted
17 Oct 2021
First published
19 Oct 2021

Chem. Commun., 2021,57, 12131-12134

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Bidirectional modulation of microRNA with a clamp-like triplex switch for enhanced and programmed gene therapy

L. Zhang, Z. Zou, Y. Lei, Z. Qing, Y. Zeng, H. Sun, F. Feng and R. Yang, Chem. Commun., 2021, 57, 12131 DOI: 10.1039/D1CC04325K

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