Issue 76, 2021
From the journal:

Chemical Communications

Glycocalixarene with luminescence for Warburg effect-mediated tumor imaging and targeted drug delivery†

Yang Li,‡a   Shengnan Liu, ORCID logo ‡b   Min Liang,c   Yujun Cui,d   Hongxia Zhao ORCID logo *a  and  Qingzhi Gao ORCID logo *a  

* Corresponding authors

a Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai, Tianjin 300072, P. R. China
E-mail: qingzhi@tju.edu.cn

b Institute of Molecular Plus, School of Chemical Engineering and Technology, Tianjin University, 92 Weijin Road, Nankai, Tianjin 300072, P. R. China

c Central Institute of Pharmaceutical Research, CSPC Pharmaceutical Group, 226 Huanghe Road, Shijiazhuang, Hebei, P. R. China

d Transplantation Center, Tianjin First Central Hospital, 24 Fukang Road, Nankai, Tianjin 300192, P. R. China

Abstract

Fluorescently labeled calix[4]arene glycoconjugates demonstrate multifunctional potential in both Warburg effect mediated tumor imaging and GLUT1 targeted drug delivery. Nitrobenzoxadiazole and mannose conjugated NBD-Man-CA was found to be selectively recognized by GLUT1 and act as a “molecular carrier” for selective tumor targeting.

Graphical abstract: Glycocalixarene with luminescence for Warburg effect-mediated tumor imaging and targeted drug delivery

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Article information

DOI
https://doi.org/10.1039/D1CC04169J
Article type
Communication
Submitted
02 Aug 2021
Accepted
25 Aug 2021
First published
27 Aug 2021

Chem. Commun., 2021,57, 9728-9731

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Glycocalixarene with luminescence for Warburg effect-mediated tumor imaging and targeted drug delivery

Y. Li, S. Liu, M. Liang, Y. Cui, H. Zhao and Q. Gao, Chem. Commun., 2021, 57, 9728 DOI: 10.1039/D1CC04169J

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