A photo-responsive chemical modulation of m6A RNA demethylase FTO

Ling Lan; Ying-Jie Sun; Li Liu; Liang Cheng

doi:10.1039/D1CC04091J

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

A photo-responsive chemical modulation of m⁶A RNA demethylase FTO†

Ling Lan,‡^a Ying-Jie Sun,‡^ab Li Liu^ab and Liang Cheng

*^ab

Author affiliations

* Corresponding authors

^a Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: chengl@iccas.ac.cn

^b University of Chinese Academy of Sciences, Beijing 100049, China

Abstract

The adenine N⁶-methylation m⁶A is a crucial modification that is associated with several biological functions. One of the two m⁶A demethylases FTO has arisen as an attractive target for the development of novel cancer therapies. Here, we describe a new design, synthesis and evaluation of a photo-responsive and selective inhibitor of FTO.

Download options Please wait...

Supplementary files

Supplementary information PDF (1427K)

Article information

DOI: https://doi.org/10.1039/D1CC04091J
Article type: Communication
Submitted: 28 Jul 2021
Accepted: 14 Sep 2021
First published: 14 Sep 2021

Download Citation

Chem. Commun., 2021,57, 10548-10551

Permissions

Request permissions

A photo-responsive chemical modulation of m⁶A RNA demethylase FTO

L. Lan, Y. Sun, L. Liu and L. Cheng, Chem. Commun., 2021, 57, 10548 DOI: 10.1039/D1CC04091J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications