Bio-inspired dynamic biomolecule assembling for fine regulation of protein activity

Wenxiao Wang; Yu Shen; Fuan Wang; Ying Liu; Xiaoqing Liu

doi:10.1039/D1CC03926A

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Bio-inspired dynamic biomolecule assembling for fine regulation of protein activity†

Wenxiao Wang,‡^ab Yu Shen,‡^a Fuan Wang,

^a Ying Liu*^a and Xiaoqing Liu

*^a

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* Corresponding authors

^a College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, P. R. China
E-mail: xps@whu.edu.cn, xiaoqingliu@whu.edu.cn

^b College of Chemistry and Chemical Engineering, Linyi University, Linyi, P. R. China

Abstract

A versatile approach for the fine control of DNA-based hierarchical assembly via dual stimuli and two assembly strategies is developed. Moreover, with a reasonable design of functional thrombin aptamer structures on the formed DNA nanoassembly, it can achieve precise regulation of thrombin activity.

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Article information

DOI: https://doi.org/10.1039/D1CC03926A
Article type: Communication
Submitted: 20 Jul 2021
Accepted: 27 Sep 2021
First published: 27 Sep 2021

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Chem. Commun., 2021,57, 11205-11208

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Bio-inspired dynamic biomolecule assembling for fine regulation of protein activity

W. Wang, Y. Shen, F. Wang, Y. Liu and X. Liu, Chem. Commun., 2021, 57, 11205 DOI: 10.1039/D1CC03926A

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Chemical Communications

Bio-inspired dynamic biomolecule assembling for fine regulation of protein activity†

Abstract

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Bio-inspired dynamic biomolecule assembling for fine regulation of protein activity

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