Deep-tissue real-time imaging of drug-induced liver injury with peroxynitrite-responsive 19F MRI nanoprobes

Ao Li; Lingxuan Li; Xing Liu; Dongxia Chen; Yifan Fan; Hongyu Lin; Jinhao Gao

doi:10.1039/D1CC03913J

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Deep-tissue real-time imaging of drug-induced liver injury with peroxynitrite-responsive ¹⁹F MRI nanoprobes†

Ao Li,

^a Lingxuan Li,

^a Xing Liu,^a Dongxia Chen,^a Yifan Fan,^a Hongyu Lin*^a and Jinhao Gao

*^a

Author affiliations

* Corresponding authors

^a The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, The Key Laboratory for Chemical Biology of Fujian Province, and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China
E-mail: hylin007@xmu.edu.cn, jhgao@xmu.edu.cn

Abstract

Peroxynitrite is an important biomarker for assessing drug-induced liver injury (DILI), which is critical for the development and use of drugs. Herein, we report the development of peroxynitrite-responsive self-assembled ¹⁹F MRI nanoprobes, which enable the sensitive imaging of peroxynitrite in L02 cells subjected to oxidative stress and living mice with DILI.

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Article information

DOI: https://doi.org/10.1039/D1CC03913J
Article type: Communication
Submitted: 20 Jul 2021
Accepted: 25 Aug 2021
First published: 25 Aug 2021

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Chem. Commun., 2021,57, 9622-9625

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Deep-tissue real-time imaging of drug-induced liver injury with peroxynitrite-responsive ¹⁹F MRI nanoprobes

A. Li, L. Li, X. Liu, D. Chen, Y. Fan, H. Lin and J. Gao, Chem. Commun., 2021, 57, 9622 DOI: 10.1039/D1CC03913J

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Chemical Communications