Issue 70, 2021
From the journal:

Chemical Communications

Thiolysis of CBD arylethers for development of highly GSH-selective fluorescent probes†

Xiaoqiang Tu,a   Lijun He,a   Haojie Huang,a   Haishun Ye,a   Lu Sun ORCID logo *b  and  Long Yi ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Organic–Inorganic Composites and Beijing Key Lab of Bioprocess, Beijing University of Chemical Technology (BUCT), Beijing 100029, China
E-mail: yilong@mail.buct.edu.cn

b Tianjin Key Laboratory of Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China
E-mail: sunlu@tmu.edu.cn

Abstract

Thiolysis of 7-cyanobenzoxadiazole (CBD) arylether was investigated for development of GSH-selective fluorescent probes for the first time. The results demonstrate that CBD-based probes have tunable reactivities and appropriate dissociation constants for GSH, and are highly GSH-selective and suitable for bioimaging.

Graphical abstract: Thiolysis of CBD arylethers for development of highly GSH-selective fluorescent probes

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Article information

DOI
https://doi.org/10.1039/D1CC03893A
Article type
Communication
Submitted
19 Jul 2021
Accepted
04 Aug 2021
First published
04 Aug 2021

Chem. Commun., 2021,57, 8802-8805

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Thiolysis of CBD arylethers for development of highly GSH-selective fluorescent probes

X. Tu, L. He, H. Huang, H. Ye, L. Sun and L. Yi, Chem. Commun., 2021, 57, 8802 DOI: 10.1039/D1CC03893A

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