Interfacial tetrazine click chemistry mediated assembly of multifunctional colloidosomes

Abstract

We demonstrate that tetrazine ligation chemistry can be employed to cross-link and assemble gold nanoparticles at the water–oil interface to create plasmonic colloidosomes. These biocompatible colloidosomes exhibit size tunability via controllable ligation kinetics and display high encapsulation efficiency, size-selective permeability, and surface-enhanced Raman scattering (SERS)-based sensing modality.