Mapping vitamin B6 metabolism by hydrazoCEST magnetic resonance imaging

Emilie Marie Sophie Patit-Tha Brun; Nicholas David Calvert; Mojmír Suchý; Alexia Kirby; Gerd Melkus; Ruslan Garipov; Christina L. Addison; Adam J. Shuhendler

doi:10.1039/D1CC03704H

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Mapping vitamin B₆ metabolism by hydrazoCEST magnetic resonance imaging†

Emilie Marie Sophie Patit-Tha Brun,‡^ab Nicholas David Calvert,

‡^ab Mojmír Suchý,^ab Alexia Kirby,^bc Gerd Melkus,^de Ruslan Garipov,^f Christina L. Addison

^ghi and Adam J. Shuhendler

*^abc

Author affiliations

* Corresponding authors

^a Dept. Chemistry & Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada
E-mail: adam.shuhendler@uottawa.ca

^b University of Ottawa Heart Institute, Ottawa, Ontario, Canada

^c Dept. Biology, University of Ottawa, Ottawa, Ontario, Canada

^d Dept. Medical Imaging, The Ottawa Hospital, Ottawa, ON, Canada

^e Dept. Radiology, University of Ottawa, Ottawa, Ontario, Canada

^f MR Solutions Ltd, Guildford, Surrey, UK

^g Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, Canada

^h Dept. Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada

ⁱ Dept. Medicine, University of Ottawa, Ottawa, Ontario, Canada

Abstract

A new CEST-MRI contrast agent, 2-HYNIC, capable of sensing aromatic aldehydes is reported. Pyridoxal 5′-phosphate, a key Vitamin B₆ metabolite necessary for >140 biotransformations was mapped by CEST-MRI in vitro and in vivo in lung cancer. 2-HYNIC provided access to this key biomarker associated with a variety of human diseases.

This article is part of the themed collection: 2021 Emerging Investigators

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Article information

DOI: https://doi.org/10.1039/D1CC03704H
Article type: Communication
Submitted: 09 Jul 2021
Accepted: 23 Aug 2021
First published: 23 Aug 2021

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Chem. Commun., 2021,57, 10867-10870

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Mapping vitamin B₆ metabolism by hydrazoCEST magnetic resonance imaging

E. M. S. P. Brun, N. D. Calvert, M. Suchý, A. Kirby, G. Melkus, R. Garipov, C. L. Addison and A. J. Shuhendler, Chem. Commun., 2021, 57, 10867 DOI: 10.1039/D1CC03704H

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